tired_fedora

Glad it helps you get by! I hadn’t heard of the rotating antihistamines trick and was curious about the mechanism, so I asked Dr. DuckDuckGo. Could’ve always been some other tolerance mechanism, like faster breakdown of the drug, which rotating might help with. The paper does mention benadryl and a handful of other substances, but it’s also ancient by research standards, so I don’t know if that applies to all antihistamines or if some circumvent tolerance induction somehow.

Does rotating them actually work? I thought they all just blocked your histamine receptors, so your body couldn’t care less just which substance did that for expressing more histamine receptors / making more histamine, thereby developing tolerance.

Edit: Yeah, so I hate to place a nocebo here, but taking a break, not rotating them, seems to be the only effective remedy to anti-histamine tolerance. That is, if taking a break is tolerable, of course. I don’t know if that has to be said but please take medical advice from your health care professional of choice and not from a lemmy comment.

Tolerance developed to one antihistamine extended to others, even though the chemical relationship was not close. Return of pharmacologic response to an antihistamine after discontinuance of the drug takes from 3 to 14 days.

https://www.jacionline.org/article/0021-8707(51)90033-0/fulltext

You could say that it was showing a reflection of the sky.

Thanks for the detailed timeline. I seem to remember that my watch stopped connecting to the server and I found a lot of mostly negative press about the acquisition, so I kinda stopped following it. I also didn’t really have the capacity to get into the weeds of it. Good to hear that it was not as bad as I perceived it at that time, after all.

Pebble is back?! I used to have one, back in the day and was super happy with it. Then it was swallowed and shut down by Fitbit to reduce competition… Best thing about it was: it actually had watchglass, so it was impact proof and water resistant, while also looking elegant. I don’t need a touch screen on my wrist: Give me a versatile, intuitive button layout and a watch that I don’t need to replace every half year!

Edit:

They have physical buttons and promise a long battery life. The reason being, Migicovsky personally hates having to routinely remove his smartwatch to charge it.

I love this man.

Demokitten

This would make for a pretty cool SCP: A place or a person whom you can’t get super close to, because space around them behaves in a fractal manner.

The answer is no, but the other way round: If your regular poop stays inside long enough, it produces diarrhea again. Google paradoxical diarrhea. And don’t try it at home.

https://www.sheknows.com/health-and-wellness/articles/2175000/69-sex-positions/

Might be a new addition to the canon.

Could be some Spiralism / Ai religion fan (club)